论文标题
短时间对单个细胞{\ sl E. Coli}的台阶刺激的极端响应
Short time extremal response to step stimulus for a single cell {\sl E. coli}
论文作者
论文摘要
在应用阶跃刺激后，以吸引剂环境突然变化的形式，受体活性和{\ sl E. coli}细胞的受体偏置急剧变化以达到其极值，然后逐渐放松到刺激后适应的水平，从而长期限制。我们执行数值模拟和精确计算，以研究细胞的短时间响应。对于活动和翻滚偏见，我们精确地得出了极端反应的条件，并与模拟找到了良好的一致性。我们还对实验可验证的预测是，在最短的时间内达到极端响应的步骤刺激的最佳尺寸。
After application of a step stimulus, in the form of a sudden change in attractant environment, the receptor activity and tumbling bias of an {\sl E. coli} cell change sharply to reach their extremal values before they gradually relax to their post-stimulus adapted levels in the long time limit. We perform numerical simulations and exact calculations to investigate the short time response of the cell. For both activity and tumbling bias, we exactly derive the condition for extremal response and find good agreement with simulations. We also make experimentally verifiable prediction that there is an optimum size of the step stimulus at which the extremal response is reached in the shortest possible time.
