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Over the past few years, there has been growing interest in developing a broad, universal, and general-purpose computer vision system. Such systems have the potential to address a wide range of vision tasks simultaneously, without being limited to specific problems or data domains. This universality is crucial for practical, real-world computer vision applications. In this study, our focus is on a specific challenge: the large-scale, multi-domain universal object detection problem, which contributes to the broader goal of achieving a universal vision system. This problem presents several intricate challenges, including cross-dataset category label duplication, label conflicts, and the necessity to handle hierarchical taxonomies. To address these challenges, we introduce our approach to label handling, hierarchy-aware loss design, and resource-efficient model training utilizing a pre-trained large vision model. Our method has demonstrated remarkable performance, securing a prestigious second-place ranking in the object detection track of the Robust Vision Challenge 2022 (RVC 2022) on a million-scale cross-dataset object detection benchmark. We believe that our comprehensive study will serve as a valuable reference and offer an alternative approach for addressing similar challenges within the computer vision community. The source code for our work is openly available at https://github.com/linfeng93/Large-UniDet.