论文标题

Metabayesdta:无编码贝叶斯测试准确性的荟萃分析,有或没有黄金标准

MetaBayesDTA: Codeless Bayesian meta-analysis of test accuracy, with or without a gold standard

论文作者

Cerullo, Enzo, Sutton, Alex J., Jones, Hayley E., Wu, Olivia, Quinn, Terry J., Cooper, Nicola J.

论文摘要

简介:尽管其适用性,但用于测试准确性荟萃分析的统计模型需要专门的知识才能实施,并且最近有必要的专业知识已增加。这是由于开发和建议使用更复杂的方法。例如Cochrane手册2版中的版本,用于系统评价诊断测试准确性。本文介绍了一个基于Web的应用程序,该应用程序扩展了先前应用程序的功能,从而使许多高级分析方法更容易访问。 方法:我们试图创建一个扩展的,独立的,贝叶斯版的元数据,(i)具有先前建议的应用程序的好处,并解决了它们的关键局限性,(ii)对于没有适合此类模型所需的特定专业知识的研究人员可以使用,并且(III)适合经验丰富的分析师。我们使用Shiny和Stan创建了应用程序。 结果:我们创建了Metabayesdta(https://crsu.shinyapps.io/metabayesdta/),该元素允许用户使用或没有金标准的用户进行测试准确性的荟萃分析。该应用程序解决了其他应用程序的几个关键局限性。例如,对于双变量模型,可以进行亚组分析,单变量元回归和比较测试精度评估。同时,对于不假定完美黄金标准的模型,该应用程序可以解释研究使用不同的参考测试的事实。 结论:由于其用户友好性和广泛的功能,Metabayesdta应该吸引各种各样的研究人员。我们预计该应用程序将鼓励更广泛地使用更高级的方法,最终将提高测试准确性评论的质量。

Introduction: Despite their applicability, statistical models used for the meta-analysis of test accuracy require specialised knowledge to implement, with the necessary level of expertise having recently increased. This is due to the development and recommendation to use more sophisticated methods; such as those in Version 2 of the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. This paper describes a web-based application that extends the functionality of previous applications, making many advanced analysis methods more accessible. Methods: We sought to create an extended, stand-alone, Bayesian version of MetaDTA, which (i) has the benefits of previously proposed applications and addresses key limitations of them, (ii) is accessible to researchers who do not have the specific expertise required to fit such models, and (iii) is suitable for experienced analysts. We created the application using Shiny and Stan. Results: We created MetaBayesDTA (https://crsu.shinyapps.io/MetaBayesDTA/), which allows users to conduct meta-analysis of test accuracy, with or without a gold standard. The application addresses several key limitations of other applications. For instance, for the bivariate model, one can conduct subgroup analysis, univariate meta-regression, and comparative test accuracy evaluation. Meanwhile, for the model which does not assume a perfect gold standard, the application can account for the fact that studies use different reference tests. Conclusions: Due to its user-friendliness and broad array of features, MetaBayesDTA should appeal to a wide variety of researchers. We anticipate that the application will encourage wider use of more advanced methods, which ultimately should improve the quality of test accuracy reviews.

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