论文标题
MVP：检测图案制造和突破突变
MVP: Detection of motif-making and -breaking mutations
论文作者
论文摘要
背景：DNA，RNA和蛋白质序列基序可以是生物学功能（例如调节，DNA碱基修饰和分子结合）的识别位点。此类主题的收益和损失可以带来重要的后果。在比较序列时，对单个变体的分析并不能赋予对这些站点影响的理解。相反，只有当这些变体与邻居以及原始序列上下文一起考虑时，这才变得可能。 结果：基序变体探测器（MVP）提出了此考虑，计算突变前后用户指定序列基序的实例，并报告了导致基序获得或损失的序列基序。 MVP可以对具有氨基酸变体数据的蛋白质进行类似的分析。该软件可在https://lpcdrp.gitlab.io/mvp上免费获得，也可以与Conda Package Manager一起安装。 结论：轻松搜索影响任何基序的变体的能力以及同时考虑相邻变体的能力使MVP成为一种多功能工具，可帮助促进比较基因组学的较少频率的维度。
Background: DNA, RNA, and protein sequence motifs can be recognition sites for biological functions such as regulation, DNA base modification, and molecular binding in general. The gain and loss of such motifs can carry important consequences. When comparing sequences, the analysis of individual variants does not impart an understanding of the impact on these sites. Rather, only when these variants considered together with their neighbors and the original sequence context does this become possible. Results: The motif-variant probe (mvp) makes this consideration, counting instances of user-specified sequence motifs before and after mutation and reports those that result in motif gain or loss. mvp can perform a similar analysis for proteins with amino acid variant data. The software is freely available at https://lpcdrp.gitlab.io/mvp and also installable with the conda package manager. Conclusions: The ability to easily search for variants affecting any motif, together with the simultaneous consideration of neighboring variants makes mvp a versatile tool to aid in a less-frequented dimension of comparative genomics.
