论文标题
呼吸节律吸收膜的潜力和非富尔科神经元的峰值
Respiratory rhythm entrains membrane potential and spiking of non-olfactory neurons
论文作者
论文摘要
近年来，几项研究倾向于显示许多大脑区域的呼吸驱动，因此可以将呼吸节奏视为促进遥远大脑区域之间交流的主时钟。但是，在嗅觉系统之外，尚不清楚神经元的膜电位（MP）是否可以构造尖峰放电，是否也不知道与呼吸相关的振荡（RRO）。为了填补这一空白，我们在不同的非野生脑区域合并了MP和LFP活动：中位前额叶皮层（MPFC），原发性体感皮层（S1），初级视觉皮层（V1）和Hippocampus（HPC），在尿素动脉粥样硬化化的老鼠中。使用呼吸周期分析，我们观察到呼吸可以调节所有记录区域的MP和尖峰放电。进一步的定量表明，大多数神经元中的RRO发作是短暂的（平均连续5个循环）。 MP中的RRO发育在很大程度上受LFP中呼吸调节的存在的影响。最后，中度超极化降低了MPFC和S1细胞内的RRO。通过显示呼吸节奏影响到非富特神经元MP的大脑活动，我们的数据支持呼吸节奏的想法可以介导远距离通信。
In recent years, several studies have tended to show a respiratory drive in numerous brain areas so that the respiratory rhythm could be considered as a master clock promoting communication between distant brain areas. However, outside of the olfactory system it is not known if respiration-related oscillation (RRo) could exist in the membrane potential (MP) of neurons neither if it can structure spiking discharge. To fill this gap, we co-recorded MP and LFP activities in different non-olfactory brain areas: median prefrontal cortex (mPFC), primary somatosensory cortex (S1), primary visual cortex (V1), and hippocampus (HPC), in urethane-anesthetized rats. Using respiratory cycle by respiratory cycle analysis, we observed that respiration could modulate both MP and spiking discharges in all recorded areas. Further quantifications revealed RRo episodes were transient in most neurons (5 consecutive cycles in average). RRo development in MP was largely influenced by the presence of respiratory modulation in the LFP. Finally, moderate hyperpolarization reduced RRo occurence within cells of mpFC and S1. By showing the respiratory rhythm influenced brain activity deep to the MP of non-olfactory neurons, our data support the idea respiratory rhythm could mediate long-range communication.
