论文标题
基于2D的现场效应晶体管作为生物传感平台的进步：从原理到生物医学应用
Advances in 2D Based Field Effect Transistors as Biosensing Platforms: From Principle to Biomedical Applications
论文作者
论文摘要
由于其独特的物理和化学性质，二维（2D）材料已在各个领域广泛使用。在它们的多样化应用中，现场效应晶体管生物传感器（Bio-FETS）有望在制造诊断生物的生物版本方面具有出色的前景，尤其是基于护理点（POC）的生物医学测试。引入2D纳米材料作为感应平台不仅可以促进其生物测定过程，而且还提供了无标签，低成本，实时，高度敏感和选择性检测不同生物分子的过程。由于有效的表面积大，环境依赖性电导率，易于功能化，生物相容性和简单的制造过程，因此高度应对生物传感应用非常需要生物传感。这篇综述全面着重于2D Bio-Fets，而更多的是干燥和湿状态。在这方面，这些生物FET分为四类，包括APTA，DNA（Geno），免疫和酶生物传感器。针对不同的生物目标讨论了每个类别的配置，检测机制和电信号处理。最后，在生物医学（真实）样品中讨论了他们作为现代医学POC测试设备的有希望的作用。
Two-dimensional (2D) materials have been used extensively in various fields due to their unique physical and chemical properties. Among their diverse applications, field-effect transistor biosensors (bio-FETs) promise a brilliant prospect in the fabrication of biodevices for diagnostics especially point of care (PoC) based biomedical testing. The introduction of 2D nanomaterials as a sensing platform not only promotes their bioassay process but also provides label-free, low-cost, real-time, highly sensitive, and selective detection of different biomolecules. 2D-based bio-FETs are highly desirable for biosensing applications due to large effective surface area, environment-dependent conductivity, being easily functionalized, biocompatible and simple fabrication processes. This review focuses comprehensively on 2D bio-FETs and more on both dry and wet states. In this regard, these bio-FETs are classified into four categories including Apta, DNA (Geno), Immuno, and enzymatic biosensors. The configuration, detection mechanism and electrical signal processing of each category are discussed in response to different biotargets. Finally, their promising roles as PoC testing devices for modern medicine are discussed in biomedical (real) samples.
