论文标题
整合素驱动的脂质聚类
Clustering of lipids driven by integrin
论文作者
论文摘要
整合素是一种重要的跨膜受体蛋白，可通过机械化学途径重塑肌动蛋白网络并将细胞膜固定在细胞外基质上。在整联蛋白介导的活性区域促进了特定脂质和脂质锚定蛋白的聚类，这对于某种类型的内吞作用是必不可少的。为了研究这一点，我们提出了一个最小的可溶解模型，其中包括整合素内外状态之间与膜的内在动力学之间的随机穿梭的相互作用。我们获得了变形和局部膜速度的分析表达，从而获得了由单个整合素介导的聚类的演变。阐明了变形，速度和脂质聚类在非单向发展及其对随机穿梭时间尺度和膜特性的依赖。
Integrin is an important transmembrane receptor protein which remodels the actin network and anchors the cell membrane towards the extracellular matrix via mechanochemical pathways. The clustering of specific lipids and lipid-anchored proteins, which is essential for a certain type of endocytosis process, is facilitated at integrin-mediated active regions. To study this, we propose a minimal exactly solvable model which includes the interplay of stochastic shuttling between integrin on and off states with the intrinsic dynamics of the membrane. We obtain an analytic expression for the deformation and local membrane velocity, and thereby the evolution of clustering mediated by a single integrin. The deformation, velocity and lipid clustering evolve nonmonotonically and their dependences on the stochastic shuttling timescales and membrane properties are elucidated.
