论文标题

使用CT和锥形梁C臂灌注成像的涡轮升级学习的肝分割

Liver Segmentation using Turbolift Learning for CT and Cone-beam C-arm Perfusion Imaging

论文作者

Haseljić, Hana, Chatterjee, Soumick, Frysch, Robert, Kulvait, Vojtěch, Semshchikov, Vladimir, Hensen, Bennet, Wacker, Frank, Brüsch, Inga, Werncke, Thomas, Speck, Oliver, Nürnberger, Andreas, Rose, Georg

论文摘要

发现采用时间分离技术(TST)的基于模型的重建可以使用C臂锥束计算机断层扫描(CBCT)改善肝脏的动态灌注成像。要使用从CT灌注数据中提取的先验知识应用TST,应从CT扫描中准确分割肝脏。需要对主要和基于模型的CBCT数据进行重建,以正确可视化和解释灌注图。这项研究提出了Turbolift Learning,该学习按照培训CT,CBCT,CBCT,CBCT TST的顺序训练多尺度关注的MultiCale Coastion UNET串行序列上的培训,使先前的培训充当后续培训阶段的培训阶段 - 解决培训数量有限的培训问题。对于CBCT TST的肝脏细分的最终任务,提出的方法的总骰子得分为0.874 $ \ pm $ 0.031和0.905 $ \ pm $ \ pm $ 0.007的6倍和4倍的交叉验证实验,分别对模型进行了统计上的显着改进,该模型仅对该模型进行了训练,该模型受过培训,该模型受过培训。实验表明,涡轮增压不仅提高了模型的整体性能,而且还使其与源自栓塞材料和截断伪像的人工制品具有鲁棒性。此外,深入分析确认了分割任务的顺序。本文显示了从CT,CBCT和CBCT TST中分割肝脏的潜力,从可用的有限训练数据中学习,这可能在将来可以用于可视化和评估灌注图的可视化和评估,以评估肝病的治疗评估。

Model-based reconstruction employing the time separation technique (TST) was found to improve dynamic perfusion imaging of the liver using C-arm cone-beam computed tomography (CBCT). To apply TST using prior knowledge extracted from CT perfusion data, the liver should be accurately segmented from the CT scans. Reconstructions of primary and model-based CBCT data need to be segmented for proper visualisation and interpretation of perfusion maps. This research proposes Turbolift learning, which trains a modified version of the multi-scale Attention UNet on different liver segmentation tasks serially, following the order of the trainings CT, CBCT, CBCT TST - making the previous trainings act as pre-training stages for the subsequent ones - addressing the problem of limited number of datasets for training. For the final task of liver segmentation from CBCT TST, the proposed method achieved an overall Dice scores of 0.874$\pm$0.031 and 0.905$\pm$0.007 in 6-fold and 4-fold cross-validation experiments, respectively - securing statistically significant improvements over the model, which was trained only for that task. Experiments revealed that Turbolift not only improves the overall performance of the model but also makes it robust against artefacts originating from the embolisation materials and truncation artefacts. Additionally, in-depth analyses confirmed the order of the segmentation tasks. This paper shows the potential of segmenting the liver from CT, CBCT, and CBCT TST, learning from the available limited training data, which can possibly be used in the future for the visualisation and evaluation of the perfusion maps for the treatment evaluation of liver diseases.

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