论文标题

自适应实验和I型错误验证和计算实验设计的严格框架

Adaptive Experiments and a Rigorous Framework for Type I Error Verification and Computational Experiment Design

论文作者

Sklar, Michael

论文摘要

该博士学位论文涵盖了自适应实验设计的多个领域的突破:(i)(第2章)精确医学时代的新型临床试验设计和统计方法。 (ii)(第3章)多军强盗理论,应用于学习医疗保健系统和临床试验。 (iii)(第4章)匪徒和协变量过程,具有有限和不可估计的武器集。 (iv)(第5章)基于模拟的自适应设计属性验证的严格框架。

This PhD thesis covers breakthroughs in several areas of adaptive experiment design: (i) (Chapter 2) Novel clinical trial designs and statistical methods in the era of precision medicine. (ii) (Chapter 3) Multi-armed bandit theory, with applications to learning healthcare systems and clinical trials. (iii) (Chapter 4) Bandit and covariate processes, with finite and non-denumerable set of arms. (iv) (Chapter 5) A rigorous framework for simulation-based verification of adaptive design properties.

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