论文标题
将微观细胞动力学桥接到细胞单层的黑质水力动力学
Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers
论文作者
论文摘要
越来越多的意识到，液晶特征可以在细胞单层的性质和动力学中发挥重要作用。在这里，我们基于相位场配方提供了基于细胞的细胞层模型，该模型将单个细胞水平的机械性能与组织的大规模nematic和流体动力学特性联系起来。特别是，我们提出了一种最小的公式，该公式可再现了众所周知的弯曲和张力的水动力学不稳定性，即活性物质的连续体 - 氢动力学配方，以及在活性和细胞弹性方面对不稳定性阈值的分析描述。此外，我们提供了用于扩展和收缩应力产生机制的流量和拓扑缺陷的定量表征和比较，并证明了活动诱导的异质性和汇合单层内间隙的自发形成。总之，这些结果有助于弥合微尺度细胞动力学与组织级集体细胞组织之间的差距。
It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that connects mechanical properties at the single cell level to large-scale nematic and hydrodynamic properties of the tissue. In particular, we present a minimal formulation that reproduces the well-known bend and splay hydrodynamic instabilities of the continuum nemato-hydrodynamic formulation of active matter, together with an analytical description of the instability threshold in terms of activity and elasticity of the cells. Furthermore, we provide a quantitative characterisation and comparison of flows and topological defects for extensile and contractile stress generation mechanisms, and demonstrate activity-induced heterogeneity and spontaneous formation of gaps within a confluent monolayer. Together, these results contribute to bridging the gap between micro-scale cell dynamics and tissue-scale collective cellular organisation.
