论文标题
控制神经元的自发触发行为
Controlling the spontaneous firing behavior of a neuron with astrocyte
论文作者
论文摘要
近年来，越来越多的证据表明，星形胶质细胞是神经胶质细胞的亚型，不仅为神经元和突触提供代谢和结构支持，而且在调节神经系统正常功能方面起着至关重要的作用。在这项工作中，我们研究了星形胶质细胞对神经元的自发发射活性的影响，该模型包括神经元 - 骨细胞对。首先，我们表明，星形胶质细胞可以通过诱导不同的发射模式（如随机和爆发峰值）来提供神经元动力学的多种性。然后，我们确定了这种行为的潜在机制，并寻找可能在不同的射击方案中具有调节作用的星形细胞因子。更具体地说，我们探讨了星形胶质细胞如何参与随机尖峰模式下神经元自发不规则不规则峰值活性的发生和控制。此外，我们系统地研究了与星形胶质细胞的细胞内环境有关的生物物理事实的变化，神经元的爆发发射状态动力学。发现与神经元耦合的星形胶质细胞可以为自发发射不规则性和爆发射击统计量（即爆发规律性和大小）提供控制机制。
Mounting evidence in recent years suggests that astrocytes, a sub-type of glial cells, not only serve metabolic and structural support for neurons and synapses but also play critical roles in regulation of proper functioning of the nervous system. In this work, we investigate the effect of astrocyte on the spontaneous firing activity of a neuron through a combined model which includes a neuron-astrocyte pair. First, we show that an astrocyte may provide a kind of multistability in neuron dynamics by inducing different firing modes such as random and bursty spiking. Then, we identify the underlying mechanism of this behavior and search for the astrocytic factors that may have regulatory roles in different firing regimes. More specifically, we explore how an astrocyte can participate in occurrence and control of spontaneous irregular spiking activity of a neuron in random spiking mode. Additionally, we systematically investigate the bursty firing regime dynamics of the neuron under the variation of biophysical facts related to the intracellular environment of the astrocyte. It is found that an astrocyte coupled to a neuron can provide a control mechanism for both spontaneous firing irregularity and burst firing statistics, i.e., burst regularity and size.
