论文标题
使用圆形光线的散射：蒙特卡洛模拟研究，对早期胃癌肿瘤侵袭的深度估计
Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study
论文作者
论文摘要
使用蒙特卡洛方法对循环极化光的散射进行了散射，对早期胃癌肿瘤侵袭的定量深度估计。使用人类胃壁及其癌的光学参数，在广泛的光谱范围内计算了从伪健康组织和癌组织中散射的光的强度和圆形极化。在600 nm和950 nm的波长下，在圆极化上具有相反符号的巨大差异。在这两个波长中，可以通过调整检测角来调节生物组织的采样深度。在健康层上具有癌层的双层pseudo-Tissues中，散射光的圆形极化程度表明，根据癌症层的厚度和深度，有系统的变化，这表明早期胃癌中癌症进展的体内定量估计的可行性。
Quantitative depth estimation of tumor invasion in early gastric cancer by scattering of circularly polarized light is computationally investigated using the Monte Carlo method. Using the optical parameters of the human stomach wall and its carcinoma, the intensity and circular polarization of light scattered from pseudo-healthy and cancerous tissues were calculated over a wide spectral range. Large differences in the circular polarization with opposite signs, together with the large intensity, are obtained at wavelengths 600 nm and 950 nm. At these two wavelengths, the sampling depth of the biological tissues can be modulated by tuning the detection angle. In bi-layered pseudo-tissues with a cancerous layer on a healthy layer and vice versa, the degree of circular polarization of scattered light shows systematic changes depending on the thickness and depth of the cancerous layer, which indicates the feasibility of in vivo quantitative estimation of cancer progression in early gastric cancer.
