论文标题
改进了生化振荡中能量耗散的估计
Improved estimation for energy dissipation in biochemical oscillations
论文作者
论文摘要
调节生命过程的时机的生化振荡需要消耗能量以在关键功能上实现良好的性能，例如相位周期的高准确性和对外部信号的高灵敏度。但是，精确估计此类系统中的能量耗散是一个巨大的挑战。在这里，基于随机正常形式理论（SNFT），我们可以得出振荡振幅和相位之间的皮尔逊相关系数，然后可以得出运输效率和相位灵敏度之间的权衡关系，这比由常规的热力学不确定关系（TUR）（tur）所产生的估计量比估计器更紧密。我们的发现表明，可以通过增强生化振荡的灵敏度来获得更精确的能量耗散估计。此外，还发现了内部噪声和振幅功率效应。
Biochemical oscillations, regulating the timing of life processes, need consume energy to achieve good performance on crucial functions, such as high accuracy of phase period and high sensitivity to external signals. However, it is a great challenge to precisely estimate the energy dissipation in such systems. Here, based on the stochastic normal form theory (SNFT), we calculate the Pearson correlation coefficient between the oscillatory amplitude and phase, and a trade-off relation between transport efficiency and phase sensitivity can then be derived, which serves as a tighter form than the estimator resulting from the conventional thermodynamic uncertainty relation (TUR). Our findings demonstrate that a more precise energy dissipation estimation can be obtained by enhancing the sensitivity of the biochemical oscillations. Moreover, the internal noise and amplitude power effects have also been discovered.
