论文标题
自动细粒肾小球病变识别肾脏病理学
Automatic Fine-grained Glomerular Lesion Recognition in Kidney Pathology
论文作者
论文摘要
识别肾小球病变是肾脏病理学诊断和治疗计划的关键。但是,诸如肾小球区域之类的肾小球结构加剧了该任务的困难。在本文中,我们引入了一种方案,以识别整个幻灯片图像中细粒的肾小球病变。首先,提出了焦点实例的结构相似性损失,以驱动模型,以精确地定位所有类型的肾小球。然后,不确定性辅助分配网络旨在执行无界盒注释的细粒度视觉分类。这种双分支形状结构从父类中提取了子类的常见特征,并产生了重新建立训练数据集的不确定性因素。幻灯片评估的结果说明了整个方案的有效性,与显着检测方法相比,平均平均精度的提高了8-22%。全面的结果清楚地证明了该方法的有效性。
Recognition of glomeruli lesions is the key for diagnosis and treatment planning in kidney pathology; however, the coexisting glomerular structures such as mesangial regions exacerbate the difficulties of this task. In this paper, we introduce a scheme to recognize fine-grained glomeruli lesions from whole slide images. First, a focal instance structural similarity loss is proposed to drive the model to locate all types of glomeruli precisely. Then an Uncertainty Aided Apportionment Network is designed to carry out the fine-grained visual classification without bounding-box annotations. This double branch-shaped structure extracts common features of the child class from the parent class and produces the uncertainty factor for reconstituting the training dataset. Results of slide-wise evaluation illustrate the effectiveness of the entire scheme, with an 8-22% improvement of the mean Average Precision compared with remarkable detection methods. The comprehensive results clearly demonstrate the effectiveness of the proposed method.