论文标题

复杂系统中间歇动力学的Koopman光谱分析:阻塞性睡眠呼吸暂停病理生理过程中的案例研究

Koopman Spectral Analysis of Intermittent Dynamics in Complex Systems: A Case Study in Pathophysiological Processes of Obstructive Sleep Apnea

论文作者

Huynh, Phat K., Setty, Arveity R., Le, Trung Q.

论文摘要

复杂的系统,例如病理生理过程,通常表现出混乱,非线性和间歇性现象。 Koopman操作员理论和Hankel的替代视图(HAVOK)模型已被广泛用于将复杂系统动力学的混乱分解为间歇性强制线性系统。尽管已经提出了间歇性强迫的统计数据来表征HAVOK模型中的间歇性,但它们不足以归因于非线性动力学的模式切换,而脂肪尾的非高斯分布源自高频率爆发,源自高频率爆发和很少观察到的间歇性强迫。本文提出了一种新的间歇性动力学分析方法,以使用光谱分解和小波分析来表征各种间歇性动力学模式的间歇相,混乱爆发和局部光谱时频。为了验证我们的方法,选择了阻塞性睡眠呼吸暂停疾病中呼吸暂停事件的间歇性行为作为情况,其中提取了心率变异性(HRV)特征。接下来,我们从HRV特征构造了Hankel矩阵,并通过Hankel矩阵的单数值分解获得了最后一个特征时间延迟坐标,该矩阵的奇异值分解为间歇性强迫输入。 OSA中强迫的统计数据证明了间歇性强迫的脂肪尾分布,这与基础OSA病理生理过程的间歇性相对应。 OSA患者的爆发持续时间的合并均值和标准偏差也被计算为分钟和分钟。小波变换的尺度图幅度和光谱分解表现出与呼吸暂停事件相关的各种主要频率和动力学模式。

Complex systems, such as pathophysiological processes, commonly exhibit chaotic, nonlinear, and intermittent phenomena. Koopman operator theory and Hankel alternative view of Koopman (HAVOK) model have been widely used to decompose the chaos of the complex system dynamics into an intermittent forced linear system. Although the statistics of the intermittent forcing have been proposed to characterize intermittencies in the HAVOK model, they were not adequate to attribute for the mode switching of nonlinear dynamics and the fat-tailed non-Gaussian distribution originated from high-frequency bursts and rarely-observed intermittent forcing. The paper proposed a new intermittency dynamics analysis approach to characterize the intermittent phases, chaotic bursts, and local spectral-temporal properties of various intermittent dynamics modes using spectral decomposition and wavelet analysis. To validate our methods, the intermittency behavior of apneic events in obstructive sleep apnea disorder was selected as the case, in which heart rate variability (HRV) features were extracted. Next, we constructed the Hankel matrix from the HRV features and obtained the last eigen time-delay coordinate by singular value decomposition of the Hankel matrix, which was modeled as an intermittent forcing input. The statistics of the forcing in OSA demonstrated the fat-tailed distribution of the intermittent forcing, which correspond to the intermittency of the underlying OSA pathophysiological process. The pooled means and standard deviations of the burst duration and the inter-burst duration across OSA patients were also calculated to be minutes and minutes. Scalogram amplitude and spectral decomposition of the wavelet transform exhibited various predominant frequencies and dynamics modes associated with apneic events.

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