论文标题

对象知道乳腺肿瘤注释的混合U-NET

An Object Aware Hybrid U-Net for Breast Tumour Annotation

论文作者

Tripathi, Suvidha, Singh, Satish Kumar

论文摘要

在临床环境中,在对组织病理学幻灯片进行数字检查期间,病理学家通过标记可疑肿瘤区域周围的粗糙边界来注释幻灯片。标记或注释通常表示为涵盖幻灯片肿瘤程度的多边形边界。这些多边形标记很难通过CAD技术模仿,因为肿瘤区域是异质的,因此分割它们需要详尽的像素明智的地面真相注释。因此,为了进行CAD分析,通常是出于研究目的,病理学家明确注释了基础真理。但是,这种语义或实例细分通常需要的注释是耗时且乏味的。因此,在这项拟议的工作中,我们试图通过通过多边形边界分割肿瘤范围来模仿病理学家,例如注释。对于多边形(如注释或分割),我们使用了活跃的轮廓,其顶点或蛇点向感兴趣的对象的边界移动以找到最小能量的区域。为了惩罚主动轮廓,我们使用了修改后的U-NET体系结构来学习惩罚值。拟议的混合深度学习模型将现代深度学习分割算法与传统的主动轮廓分割技术融合在一起。该模型均针对最新的语义细分和用于针对当代工作的绩效评估的混合模型进行了测试。获得的结果表明,可以通过开发这样的混合模型来通过经典分割方法(例如主动轮廓和通过语义分割深度学习模型)来整合域知识的混合模型来实现诸如注释。

In the clinical settings, during digital examination of histopathological slides, the pathologist annotate the slides by marking the rough boundary around the suspected tumour region. The marking or annotation is generally represented as a polygonal boundary that covers the extent of the tumour in the slide. These polygonal markings are difficult to imitate through CAD techniques since the tumour regions are heterogeneous and hence segmenting them would require exhaustive pixel wise ground truth annotation. Therefore, for CAD analysis, the ground truths are generally annotated by pathologist explicitly for research purposes. However, this kind of annotation which is generally required for semantic or instance segmentation is time consuming and tedious. In this proposed work, therefore, we have tried to imitate pathologist like annotation by segmenting tumour extents by polygonal boundaries. For polygon like annotation or segmentation, we have used Active Contours whose vertices or snake points move towards the boundary of the object of interest to find the region of minimum energy. To penalize the Active Contour we used modified U-Net architecture for learning penalization values. The proposed hybrid deep learning model fuses the modern deep learning segmentation algorithm with traditional Active Contours segmentation technique. The model is tested against both state-of-the-art semantic segmentation and hybrid models for performance evaluation against contemporary work. The results obtained show that the pathologist like annotation could be achieved by developing such hybrid models that integrate the domain knowledge through classical segmentation methods like Active Contours and global knowledge through semantic segmentation deep learning models.

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