论文标题
β2微球蛋白的进化和突变
Evolution and Mutations of Beta 2 Microglobulin
论文作者
论文摘要
在这里，我们从β-2微球蛋白的水平形状来研究了β-2微球蛋白的演变，这种理论构建体揭示了重要的趋势。许多蛋白质的动力学在很大程度上是由蛋白质本身与覆盖蛋白质薄膜之间的相互作用驱动的。 \ b {eta} 2M构成免疫球蛋白超家族的基本建筑单位；其从鸡到小鼠再到人类的氨基酸序列的演变提供了有关其多种功能的新信息。我们的流体动力学方法涉及拓扑形状进化的概念，以达到优化功能的关键点。结果与实验有关小鼠人类进化的细节以及危险的天然淀粉样蛋白聚集突变D76N和其他六个DN测试突变非常吻合。
Here we examine the evolution of beta-2 microglobulin in terms of its hydropathic shapes, a theoretical construct that has revealed important trends. The dynamics of many proteins are largely driven by interactions between the protein itself and the thin water film that covers it. \b{eta}2m constitutes the basic building unit of the immunoglobulin superfamily; the evolution of its amino acid sequences from chickens to mice to humans provides new information about its multiple functions. Our hydrodynamic method involves concepts of topological shape evolution towards a critical point for optimized functions. The results are in excellent agreement with experiment for the details of the mouse-human evolution, as well as both the dangerous natural amyloid aggregation mutation D76N, and six other DN test mutations.
