论文标题
对短DNA熔化的拥挤效果：与实验进行比较
The crowding effect on the melting of short DNA: Comparison with experiments
论文作者
论文摘要
我们研究人群对均质和异质DNA分子的融化曲线的影响。我们发现短DNA分子的融化曲线，并将我们的发现与实验进行比较。我们考虑沿链中人群的一些随机分布，并通过发现与实验的最佳匹配，我们试图在Ghosh \ cite \ cite {ghosh_pnas_2020}的实验发现中识别人群的位置。我们还研究了在链中仅存在一个crowder的情况下，不同长度（25、50、75）的均质DNA分子的融化。通过将乌鸦的位置从一端到另一端变化，我们发现熔化温度容易受到乌鸦在末端的位置的影响。同时，由于乌鸦的位置，对熔化温度的影响最小。 {\ it in Vivo}，人群的强度可能会随着链条而变化。我们研究了在五个具有不同力量的人群的情况下，长期异质链的融化。我们发现，在强度可变的人群存在下，DNA的熔化过程存在显着差异。
We study the effect of crowders on the melting profile of homogeneous and heterogeneous DNA molecules. We find out the melting profile of short DNA molecules and compare our findings with the experiments. We consider some random distribution of crowders along the chain, and by finding out the best match with the experiments, we attempt to identify the location of crowders in the experimental findings of Ghosh \cite{Ghosh_PNAS_2020}. We also study the melting of homogeneous DNA molecules of different lengths (25, 50, 75) in the presence of only one crowder in the chain. By varying the location of the crowder from one end to the other, we find that the melting temperature is susceptible to the location of the crowder at the ends. At the same time, there is minimal effect on the melting temperature due to the location of the crowder. {\it In vivo}, the strength of a crowders may vary along the chain. We study the melting of long heterogeneous chain in presence of five crowders of different strength. We find that there is a significant variation in the melting process of DNA in presence of crowders of variable strength.
