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We explore the problem of automatically inferring the amount of kilocalories used by human during physical activity from his/her video observation. To study this underresearched task, we introduce Vid2Burn -- an omni-source benchmark for estimating caloric expenditure from video data featuring both, high- and low-intensity activities for which we derive energy expenditure annotations based on models established in medical literature. In practice, a training set would only cover a certain amount of activity types, and it is important to validate, if the model indeed captures the essence of energy expenditure, (e.g., how many and which muscles are involved and how intense they work) instead of memorizing fixed values of specific activity categories seen during training. Ideally, the models should look beyond such category-specific biases and regress the caloric cost in videos depicting activity categories not explicitly present during training. With this property in mind, Vid2Burn is accompanied with a cross-category benchmark, where the task is to regress caloric expenditure for types of physical activities not present during training. An extensive evaluation of state-of-the-art approaches for video recognition modified for the energy expenditure estimation task demonstrates the difficulty of this problem, especially for new activity types at test-time, marking a new research direction. Dataset and code are available at https://github.com/KPeng9510/Vid2Burn.