学术文献库

Nanomedicine research started exploring the combination of therapy and diagnostics, so-called theranostics, to offer a more flexible care with improved outcome. As magnetic nanoparticles show great potential in many diagnostic and therapeutic applications, they are prime candidates to be used in a theranostic setting. This perspective gives an overview of state-of-the-art magnetic nanoparticle-based imaging techniques and theranostic applications and discusses their opportunities and challenges. To address these challenges and exploit these opportunities to the fullest, we provide three promising research directions. The first considers novel magnetic field sequences, utilizing the rich magnetic dynamics of the particles, which boost the capabilities of many nanoparticle-based applications. Secondly ,we introduce the concept of smart theranostics based on feedback mechanisms between the particle applications and their supporting imaging procedure to enhance the performance of both and allow real-time monitoring of treatment efficiency. Finally, we show how data-driven models could enhance therapy and diagnostics, and handle the platform's large amount of data and decision support algorithms. The latter research track also includes hybrid models in which physics-based and data-driven models are combined to overcome challenges of applications with limited data, as well as to uncover unknown nanoparticle dynamics. Contrasting other literature, which mainly focuses on developing magnetic nanoparticles with the right characteristics, we put forward advances in magnetic nanoparticle imaging techniques and applications to enable the use of a broader range of magnetic nanoparticles in theranostics. We encourage researchers to also investigate these aspects to advance theranostic applications of magnetic nanoparticles to clinical environments.