论文标题
从遗传网络的读数中的交易位
Trading bits in the readout from a genetic network
论文作者
论文摘要
在遗传网络中，与生物体相关的信息由转录因子分子的浓度表示。为了提取此信息，细胞必须有效地“测量”这些浓度，但是这些测量值的精度存在物理限制。我们在测量浓度和可以提取的相关信息位的精确度之间进行了探索，以早期蝇胚中的GAP基因网络为例。我们认为胚胎中的细胞可以提取有关其位置的所有可用信息，但前提是浓度测量接近物理限制到信息能力。这些限制需要观察到具有对转录因子组合的敏感性的增强子元素的增殖，但是不需要对这些多个增强子的参数进行微调。
In genetic networks, information of relevance to the organism is represented by the concentrations of transcription factor molecules. In order to extract this information the cell must effectively "measure"' these concentrations, but there are physical limits to the precision of these measurements. We explore this trading between bits of precision in measuring concentration and bits of relevant information that can be extracted, using the gap gene network in the early fly embryo as an example. We argue that cells in the embryo can extract all the available information about their position, but only if the concentration measurements approach the physical limits to information capacity. These limits necessitate the observed proliferation of enhancer elements with sensitivities to combinations of transcription factors, but fine tuning of the parameters of these multiple enhancers is not required.
