论文标题
将剂量组与阴性对照组或安慰剂进行比较的封闭测试程序
Closed test procedures for the comparison of dose groups against a negative control group or placebo
论文作者
论文摘要
将剂量组与通常通过Williams趋势测试的顺序限制的对照组进行比较。在这里，作为替代方案，考虑了封闭测试程序的两个变体，其中一个在分区假设中使用了全局威廉姆斯测试，而另一种用于此目的的成对对比度测试。提供了相关的R软件。
Dose groups are compared with a control assuming an order restriction usually by the Williams trend test. Here, as an alternative, two variants of the closed testing procedure are considered, one where global Williams tests are used in the partition hypotheses, and another where pairwise contrast tests are used for this purpose. Related R software is provided.
