论文标题
结合热膜曲率诱导蛋白
Binding of thermalized and active membrane curvature-inducing proteins
论文作者
论文摘要
通过分析和数值方法的组合研究了由曲率诱导蛋白的结合引起的膜相行为。在结合和解开之间的详细平衡下的热平衡中，膜表现出三个阶段：一个均匀的平坦相（U），结合均匀的平面相（b）和一个分离/瓦楞纸（SC）。在SC阶段，结合蛋白会形成六角形订购的碗形域。 U和SC阶段之间以及B和SC阶段之间的过渡分别为二阶和一阶。在蛋白质或高表面张力的较小的自发曲率下，B和SC相之间的过渡变得连续。此外，在刚性蛋白之间的casimir样相互作用驱动的零自发曲率下，U和B相之间的一阶跃迁。此外，通过以恒定速率添加主动结合并解开未连接来研究非平衡动力学。主动结合和解开过程改变了SC相的稳定性。
Membrane phase behavior induced by the binding of curvature-inducing proteins is studied by a combination of analytical and numerical approaches. In thermal equilibrium under the detailed balance between binding and unbinding, the membrane exhibits three phases: an unbound uniform flat phase (U), a bound uniform flat phase (B), and a separated/corrugated phase (SC). In the SC phase, the bound proteins form hexagonally-ordered bowl-shaped domains. The transitions between the U and SC phases and between the B and SC phases are second order and first order, respectively. At a small spontaneous curvature of the protein or high surface tension, the transition between B and SC phases becomes continuous. Moreover, a first-order transition between the U and B phases is found at zero spontaneous curvature driven by the Casimir-like interactions between rigid proteins. Furthermore, nonequilibrium dynamics is investigated by the addition of active binding and unbinding at a constant rate. The active binding and unbinding processes alter the stability of the SC phase.
