论文标题

稳定肾脏交换问题的新型整数编程模型

Novel Integer Programming models for the stable kidney exchange problem

论文作者

Klimentova, Xenia, Biró, Péter, Viana, Ana, Costa, Virginia, Pedroso, João Pedro

论文摘要

肾脏交换计划(KEP)代表了患有末期肾脏疾病的患者移植的另一种可能性。如果患者有一个愿意与患者不兼容的愿意的活体捐助者,则患者会(D)可以加入一对不兼容的对,并且,如果患者与捐助者之间的兼容性有两个,我们的对越来越多,则可以交换它们之间的器官。该问题可以建模为一个整数程序,通常,该程序旨在查找应选择的对移植的对,以便执行最大数量的移植数量。在本文中,我们认为,对于每个患者,可能存在比他/她可以收到的器官的偏好订单,因为患者可能与几个捐赠者兼容,但可能比某些人比其他器官兼容。在此设置下,目的是找到最大的基数稳定交换,这是不存在阻止周期的解决方案。为此,我们根据众所周知的边缘和周期公式提出了三个新型整数编程模型。这些配方是针对在严格的偏好下找到稳定且强烈稳定的交流的调整,并且对于可能存在偏好的纽带的情况。此外,我们研究了一种情况,可以通过解决最大基数与溶液中允许的阻塞周期数之间的权衡来放松稳定性。通过在广泛的实例上进行广泛的计算实验来评估所提出模型的有效性。

Kidney exchange programs (KEP's) represent an additional possibility of transplant for patients suffering from end stage kidney disease. If a patient has a willing living donor with whom the patient is not compatible, the pair patient--donor can join a pool of incompatible pairs and, if compatibility between patient and donor in two our more pairs exists, organs can be exchanged between them. The problem can be modeled as an integer program that, in general, aims at finding the pairs that should be selected for transplant such that maximum number of transplants is performed. In this paper we consider that for each patient there may exist a preference order over the organs that he/she can receive, since a patient may be compatible with several donors but may have a better fit over some than over others. Under this setting, the aim is to find the maximum cardinality stable exchange, a solution where no blocking cycle exists. For this purpose we propose three novel integer programming models based on the well-known edge and cycle formulations. These formulations are adjusted for both finding stable and strongly stable exchanges under strict preferences and for the case when ties in preferences may exist. Furthermore, we study a situation when the stability requirement can be relaxed by addressing the trade-off between maximum cardinality versus number of blocking cycles allowed in a solution. The effectiveness of the proposed models is assessed through extensive computational experiments on a wide set of instances.

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