论文标题
内部再狭窄的有限元建模
Finite element modelling of in-stent restenosis
论文作者
论文摘要
从冠心病的角度来看，支架的发展在降低相关的死亡率方面显着远，药物洗脱支架是创新和有效解决方案的缩影。在这项工作中，考虑到重要的生长因子之一及其对动脉壁成分的影响之一，对内部再狭窄的复杂过程进行了建模。在这方面采用了多物理建模方法。来自文献的实验研究已被用来假设管理方程式和相应的参数。使用交错的解决方案策略来捕获运输现象以及支架植入后的生长和重塑。本文开发的模型是一种工具，可以根据持续的内皮损伤以及支架对动脉腔内的延伸，以预测内部再狭窄。关键词：内部再狭窄，光滑的粘液细胞，血小板衍生的生长因子，细胞外基质，生长
From the perspective of coronary heart disease, the development of stents has come significantly far in reducing the associated mortality rate, drug-eluting stents being the epitome of innovative and effective solutions. Within this work, the intricate process of in-stent restenosis is modelled considering one of the significant growth factors and its effect on constituents of the arterial wall. A multiphysical modelling approach is adopted in this regard. Experimental investigations from the literature have been used to hypothesize the governing equations and the corresponding parameters. A staggered solution strategy is utilised to capture the transport phenomena as well as the growth and remodeling that follows stent implantation. The model herein developed serves as a tool to predict in-stent restenosis depending on the endothelial injury sustained and the protuberance of stents into the lumen of the arteries. Keywords: in-stent restenosis, smooth mucsle cells, platelet-derived growth factor, extracellular matrix, growth
