论文标题
DNA构象变化对大分子变形分量偶联的影响
The effect of DNA conformation changes on the coupling of the macromolecule deformation components
论文作者
论文摘要
DNA大分子的变形模型是通过对两种类型的变形组成部分进行的：外部和内部的。外部组件描述了双螺旋的弯曲，扭曲和拉伸。内部组件 - 双螺旋内部的构象迁移率。在工作中，考虑到外部成分（变形）与内部成分（构象变化）的耦合，认为DNA大分子的变形被认为是考虑到外部成分的耦合。在任务考虑下，考虑了大分子扭转 - 拉伸耦合以及扭曲和内部组件之间的耦合。在这些条件下为变形组件获得的解决方案允许在unvind（越来越多）的伸展组件中更改响应的特征，以依赖于施加力的扭曲组件。从单个分子实验中知道，变形特征从压缩到达到临界不相关力的张力（反之亦然）变形特征的变化变为在临界张力时变形为放松）。双螺旋的这种意外行为的性质已在本工作中阐明了内部组件。获得的溶液及其符合实验结果表明，在PN范围内，在动作力下的双螺旋构象力学中，内部和外部组件之间耦合的重要作用。
The model of the deformation of DNA macromolecule is developed with the accounting of two types of components of deformation: external and internal. External components describe the bend, twist and stretch of the double helix. The internal component - the conformational mobility inside of the double helix. In the work the deformation of DNA macromolecule is considered taking into account the coupling of the external component (of deformation) with the internal component (of conformational change). Under the task consideration the macromolecule twist-stretch coupling and coupling between twist and internal component are taken into account. The solution obtained in these conditions for the deformation components allows changing the character of respond in stretch component on unwind (overwind) in dependence on the applied force to twist component. The changing of the character of deformation from compression to tension achieving of critical untwisting force (and vise versa the changing of the character of deformation from overwind to unwind at critical tension force)is known from the single molecular experiments. The nature of such unexpected behavior of double helix have clarified in the present work by including in consideration the internal component. The obtained solutions and their conformity to experimental results show the essential role of coupling between internal and external components in the double helix conformational mechanics under action force in pN range.
