论文标题
建模纳米孔中捆绑DNA结构的当前调制
Modeling the Current Modulation of Bundled DNA Structures in Nanopores
论文作者
论文摘要
我们研究了纳米孔中捆绑DNA纳米结构的盐依赖性电流调节。为此，我们为2x2折纸结构开发了四个仿真模型，详细程度升高：从平均场水平到DNA结构的全原子表示。我们观察到一致的孔电导率，这是所有四个模型的盐浓度的函数。但是，我们的数据与最近对类似系统的实验研究的比较显示出明显的偏差。我们讨论了差异的可能原因，并提出了向我们的模型进行扩展以进行未来调查的原因。
We investigate the salt-dependent current modulation of bundled DNA nanostructures in a nanopore. To this end, we developed four simulation models for a 2x2 origami structure with increasing level of detail: from the mean-field level to an all-atom representation of the DNA structure. We observe a consistent pore conductivity as a function of salt concentration for all four models. However, a comparison of our data to recent experimental investigations on similar systems displays significant deviations. We discuss possible reasons for the discrepancies and propose extensions to our models for future investigations.
