论文标题
建模细胞扩散，运动和蛋白质迁移的框架
A framework for modeling cells spreading, motility and the relocation of proteins on advecting lipid membranes
论文作者
论文摘要
细胞在扩散和运动过程中的响应由多个多物理事件决定，这些事件是由细胞外提示触发的，并在不同的时间标准处发生。为此，对于“流变学”或“机械响应”，提供具有材料力学的经典概念并不完全合适。相反，一个单元是一个活着的系统，具有显示可再现反应的成分，对于单个应力纤维或生物聚合物肌动蛋白网络的机械响应的{\ em {收缩}}，但该响应是在不可预测且可重复可重复的方式中对外部线索的响应而重组的。意识到这种复杂性，在本说明中，我们旨在制定一个多物理框架，用于建模细胞扩散和运动性，并考虑蛋白质在延伸脂质膜上的重定位。
The response of cells during spreading and motility is dictated by several multi-physics events, which are triggered by extracellular cues and occur at different time-scales. For this sake, it is not completely appropriate to provide a cell with classical notions of the mechanics of materials, as for "rheology" or "mechanical response". Rather, a cell is an alive system with constituents that show a reproducible response, as for the {\em{contractility}} for single stress fibers or for the mechanical response of a biopolymer actin network, but that reorganize in response to external cues in a non-exactly-predictable and reproducible way. Aware of such complexity, in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility, accounting for the relocation of proteins on advecting lipid membranes.
