论文标题
使用Bissable低聚物的随机共振检测单分子
Detection of single molecules using stochastic resonance of bistable oligomers
论文作者
论文摘要
我们的计算机模拟表明，热响应聚合物的短寡聚片段的大规模构象动力学类似于非线性双向系统的机械运动。这些低聚物表现出自发的振动和由热噪声激活的随机共振。我们已经观察到将分子货物连接到低聚物时，自发振动和随机共振模式的合理移动。所有这些效果表明，双向低聚物可以用作能够检测单分子的操作单位。
Our computer simulations have shown that the large-scale conformational dynamics of a short oligomeric fragment of thermoresponsive polymers resemble the mechanical movement of nonlinear bistable systems. The oligomers demonstrate spontaneous vibrations and stochastic resonance activated by the thermal noise. We have observed reasonable shifts of the spontaneous vibrations and stochastic resonance modes when attaching a molecular cargo to the oligomer. All these effects indicate that bistable oligomers may work as operational units capable of detecting single molecules.
