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Graph pattern mining (GPM) is used in diverse application areas including social network analysis, bioinformatics, and chemical engineering. Existing GPM frameworks either provide high-level interfaces for productivity at the cost of expressiveness or provide low-level interfaces that can express a wide variety of GPM algorithms at the cost of increased programming complexity. Moreover, existing systems lack the flexibility to explore combinations of optimizations to achieve performance competitive with hand-optimized applications. We present Sandslash, an in-memory Graph Pattern Mining (GPM) framework that uses a novel programming interface to support productive, expressive, and efficient GPM on large graphs. Sandslash provides a high-level API that needs only a specification of the GPM problem, and it implements fast subgraph enumeration, provides efficient data structures, and applies high-level optimizations automatically. To achieve performance competitive with expert-optimized implementations, Sandslash also provides a low-level API that allows users to express algorithm-specific optimizations. This enables Sandslash to support both high-productivity and high-efficiency without losing expressiveness. We evaluate Sandslash on shared-memory machines using five GPM applications and a wide range of large real-world graphs. Experimental results demonstrate that applications written using Sandslash high-level or low-level API outperforms state-of-the-art GPM systems AutoMine, Pangolin, and Peregrine on average by 13.8x, 7.9x, and 5.4x, respectively. We also show that these Sandslash applications outperform expert-optimized GPM implementations by 2.3x on average with less programming effort.