论文标题
燃烧损伤的一维形态弹性模型：灵敏度分析和可行性研究
A one-dimensional morphoelastic model for burn injuries: sensitivity analysis and a feasibility study
论文作者
论文摘要
我们考虑了一个描述燃烧后疤痕收缩的一维形态弹性模型。该模型描述了皮肤真皮层的位移以及组织中有效的欧拉菌株的发展。除这些组件外，该模型还包含创伤后皮肤修复中重要作用的组件。这些成分是信号分子，成纤维细胞，肌纤维细胞和胶原蛋白。我们对模型的许多参数进行灵敏度分析，并将结果用于可行性研究。在这项研究中，我们测试该模型是否适合预测不同年龄组的收缩程度。为此，我们进行了广泛的文献综述以找到参数值。从灵敏度分析中，我们得出的结论是，最敏感的参数是真皮层中的平衡胶原蛋白浓度，成纤维细胞和肌纤维细胞的凋亡率以及信号分子的分泌速率。此外，尽管我们可以使用该模型来模拟不同年龄段的不同收缩密度，但我们的结果与诊所中所见。
We consider a one-dimensional morphoelastic model describing post-burn scar contraction. This model describes the displacement of the dermal layer of the skin and the development of the effective Eulerian strain in the tissue. Besides these components, the model also contains components that play a major role in skin repair after trauma. These components are signaling molecules, fibroblasts, myofibroblasts, and collagen. We perform a sensitivity analysis for many parameters of the model and use the results for a feasibility study. In this study, we test whether the model is suitable for predicting the extent of contraction in different age groups. To this end, we conduct an extensive literature review to find parameter values. From the sensitivity analysis, we conclude that the most sensitive parameters are the equilibrium collagen concentration in the dermal layer, the apoptosis rate of fibroblasts and myofibroblasts, and the secretion rate of signaling molecules. Further, although we can use the model to simulate distinct contraction densities in different age groups, our results differ from what is seen in the clinic.
