论文标题
鞭毛长度控制通过电动传输在单一晶状体中的控制：生长动力学和长度波动的相关性
Flagellar length control in monoflagellates by motorized transport: growth kinetics and correlations of length fluctuations
论文作者
论文摘要
细胞如何进行自组织以使其附属于各自功能方便的特定长度？一个单元用来测量这些附属的长度的“统治者”？细胞运输结构如何在这些附属物的细胞体和远端尖端之间建立建筑材料，从而在其一生的各个阶段调节其动态长度？这些问题中的一些在此处是在称为鞭毛（也称为cilium）的特定细胞附件的背景下解决的。根据伽利略的开创性思想，已成功地使用了一种“飞行时间”（TOF）机制，以解释双叶酸绿色藻类对鞭毛的长度控制。使用相同的TOF机制，我们在这里开发了一种随机模型，用于在两种不同类型的单细胞生物体中鞭毛动力学。这些单晶状体的一个独特特征是，它们在短时间内变成了瞬时的多壁球。我们模型中鞭毛的平均长度再现了在实验中观察到的其时间变化的趋势。此外，为了探测给定细胞的动态鞭毛之间的细胞内分子通信，我们通过Monte Carlo Simulation计算了在细胞周期的多量化阶段的长度波动中的相关性。
How does a cell self-organize so that its appendages attain specific lengths that are convenient for their respective functions? What kind of 'rulers' does a cell use to measure the length of these appendages? How does a cell transport structure building materials between the cell body and distal tips of these appendages so as to regulate their dynamic lengths during various stages of its lifetime? Some of these questions are addressed here in the context of a specific cell appendage called flagellum (also called cilium). A "time of flight" (ToF) mechanism, adapted from the pioneering idea of Galileo, has been used successfully very recently to explain the length control of flagella by a biflagellate green algae. Using the same ToF mechanism, here we develop a stochastic model for the dynamics of flagella in two different types of monoflagellate unicellular organisms. A unique feature of these monoflagellates is that these become transiently multi-flagellated during a short span of their life time. The mean length of the flagella in our model reproduce the trend of their temporal variation observed in experiments. Moreover, for probing the intracellular molecular communication between the dynamic flagella of a given cell, we have computed the correlation in the fluctuations of their lengths during the multiflagellated stage of the cell cycle by Monte Carlo simulation.
