论文标题
电路病毒是否介导了BAT和PANGOLIN冠状病毒之间的重组，从而产生SARS-COV-2？
Did circoviruses intermediate the recombination between bat and pangolin coronaviruses, yielding SARS-CoV-2?
论文作者
论文摘要
自从第一个关于2019年冠状病毒（COV）疾病（COVID-19）的报道以来，该疾病是由中国瓦省武汉严重急性呼吸综合症病毒（SARS-COV-2）引起的，科学家们全天候都在全天候工作，以寻找其起源问题的合理答案。尽管有关SARS-COV-2的科学文章数量正在增加，但其起源仍然存在许多差距。所有研究均未在其他动物中发现冠状病毒，该冠状病毒与人类SARS-COV2更相似，而不是蝙蝠病毒，而BAT病毒被认为是主要储层。在本文中，我们基于DNA和SARS-COV病毒之间可能的重组，以解释SRAS-COV-2的兴起，以解决新的假设。 By comparing SARS-CoV-2 and related CoVs with circoviruses (CVs), we found strong sequence similarity of the genomic region at the 3-end of Bat-CoV ORF1a and the origin of replication (Ori) of porcine CV type 2 (PCV2), as well as similar RNA secondary structures of the region encompassing the cleavage site of CoV S gene with the PCV2 Ori.这构成了支持可能重组的主要证据，这种情况可能解释了SARS-COV-2的起源。
Since the first reports of a coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome virus (SARS-CoV-2) in Wuhan, Hubei province, China, scientists are working around the clock to find sound answers to the issue of its origin. While the number of scientific articles on SARS-CoV-2 is increasing, there are still many gaps as to its origin. All studies failed to find a coronavirus in other animals that is more similar to human SARS-COV2 than the bat virus, considered to be the primary reservoir. In this paper we address a new hypothesis, based on a possible recombination between a DNA and SARS-CoV viruses, to explain the rise of SRAS-CoV-2. By comparing SARS-CoV-2 and related CoVs with circoviruses (CVs), we found strong sequence similarity of the genomic region at the 3-end of Bat-CoV ORF1a and the origin of replication (Ori) of porcine CV type 2 (PCV2), as well as similar RNA secondary structures of the region encompassing the cleavage site of CoV S gene with the PCV2 Ori. This constitutes a primary evidence that supports a possible recombination, which occurrence might explain the origin of SARS-CoV-2.
