论文标题

使用A-FSI血流模型的动脉血流动力学中粘弹性参数的不确定性定量

Uncertainty quantification of viscoelastic parameters in arterial hemodynamics with the a-FSI blood flow model

论文作者

Bertaglia, Giulia, Caleffi, Valerio, Pareschi, Lorenzo, Valiani, Alessandro

论文摘要

这项工作旨在在人动脉血流动力学的一维建模中识别和量化与弹性和粘弹性参数相关的不确定性,这些不确定性表征了动脉壁行为。所选的不确定参数被建模为随机高斯分布的变量,使随机性成为管理方程的系统。最初在模型方程式上验证了所提出的方法,并提供了一项彻底的收敛研究,该研究确认了随机搭配方法的光谱精度以及选择用于解决数学模型的IMEX有限体积方案的二阶精度。然后,将单变量和多变量不确定的量化分析应用于A-FSI血流模型,涉及基线和特定于患者的单极测试用例。将流速和速度波形的变异性与压力和面积的变异性进行比较时,描述了不同的灵敏度,后者对船只壁的机械表征的参数不确定性更为敏感。考虑了简单的弹性和更现实的粘弹性本构定律表明,粘度参数的极大不确定性在预测压力波形的预测中起着重要作用,从而扩大了该变量的置信区间。体内记录的患者特异性压力数据属于所提出的方法论获得的输出的置信区间,并且对计算压力的期望与记录的波形相当。

This work aims at identifying and quantifying uncertainties related to elastic and viscoelastic parameters, which characterize the arterial wall behavior, in one-dimensional modeling of the human arterial hemodynamics. The chosen uncertain parameters are modeled as random Gaussian-distributed variables, making stochastic the system of governing equations. The proposed methodology is initially validated on a model equation, presenting a thorough convergence study which confirms the spectral accuracy of the stochastic collocation method and the second-order accuracy of the IMEX finite volume scheme chosen to solve the mathematical model. Then, univariate and multivariate uncertain quantification analyses are applied to the a-FSI blood flow model, concerning baseline and patient-specific single-artery test cases. A different sensitivity is depicted when comparing the variability of flow rate and velocity waveforms to the variability of pressure and area, the latter ones resulting much more sensitive to the parametric uncertainties underlying the mechanical characterization of vessel walls. Simulations performed considering both the simple elastic and the more realistic viscoelastic constitutive law show that the great uncertainty of the viscosity parameter plays a major role in the prediction of pressure waveforms, enlarging the confidence interval of this variable. In-vivo recorded patient-specific pressure data falls within the confidence interval of the output obtained with the proposed methodology and expectations of the computed pressures are comparable to the recorded waveforms.

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源