论文标题
同时实时fMRI和EEG神经反馈对用脑电磁断层扫描评估的主要抑郁症的影响
Effects of simultaneous real-time fMRI and EEG neurofeedback in major depressive disorder evaluated with brain electromagnetic tomography
论文作者
论文摘要
最近，我们报道了一项情绪自我调节研究（Zotev等，2020年），其中重度抑郁症患者（MDD）使用同时实时fMRI和EEG Neurofeepback（RTFMRI-EEG-NF）上调了两个fMRI和两个与MDD相关的EEG活性测量。目标措施包括左杏仁核和左侧扣带回皮层的fMRI活性，以及Alpha带（FAA）（FAA）和High-beta带（FBA）中的额叶EEG不对称性。在这里，我们将精确的低分辨率脑电磁断层扫描（ELORETA）在RTFMRI-EEG-NF程序中研究EEG源活动。探索性分析揭示了前额叶区域中上α和高β电流源密度的半球横向变化，这与RTFMRI-EEG-NF任务期间FAA和FBA的上调一致。观察到杏仁核中当前源密度的类似侧向变化。前额叶上α电流密度变化显示与Anhedonia症的严重程度显着负相关。前额叶高β电流密度的变化与合并症焦虑的降低一致。与以前的Loreta研究结果的比较表明，RTFMRI-EEG-NF培训对MDD患者有益，并且可能具有纠正与Anhedonia和MDD中合并症焦虑相关的功能缺陷的能力。
Recently, we reported an emotion self-regulation study (Zotev et al., 2020), in which patients with major depressive disorder (MDD) used simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) to upregulate two fMRI and two EEG activity measures, relevant to MDD. The target measures included fMRI activities of the left amygdala and left rostral anterior cingulate cortex, and frontal EEG asymmetries in the alpha band (FAA) and high-beta band (FBA). Here we apply the exact low resolution brain electromagnetic tomography (eLORETA) to investigate EEG source activities during the rtfMRI-EEG-nf procedure. The exploratory analyses reveal significant changes in hemispheric lateralities of upper alpha and high-beta current source densities in the prefrontal regions, consistent with upregulation of the FAA and FBA during the rtfMRI-EEG-nf task. Similar laterality changes are observed for current source densities in the amygdala. Prefrontal upper alpha current density changes show significant negative correlations with anhedonia severity. Changes in prefrontal high-beta current density are consistent with reduction in comorbid anxiety. Comparisons with results of previous LORETA studies suggest that the rtfMRI-EEG-nf training is beneficial to MDD patients, and may have the ability to correct functional deficiencies associated with anhedonia and comorbid anxiety in MDD.
