论文标题
轴突丘陵电流允许使用基于钻石量子缺陷的矢量磁力测定法进行单神经元 - 三维功能神经成像
Axon Hillock Currents Allow Single-Neuron-Resolution 3-Dimensional Functional Neural Imaging Using Diamond Quantum Defect-Based Vector Magnetometry
论文作者
论文摘要
磁场传感随着最近的进步而成为一种可行的替代方法，可以通过传感动作电位相关的磁场（APMF）来测量大脑中单神经元的功能活性。由于大小的大小，可以测量大型蠕虫的大轴突的测量。在哺乳动物的大脑中，轴突大小，其数量和路线，使用此类功能成像方法限制。借助哺乳动物锥体神经元的分段模型，我们表明轴突小丘中轴内电流的APMF比其他神经元位置大两个数量级。模拟了一系列神经元的自然峰值活性的预期二维矢量磁场图，模拟了宽阔的钻石氮化中心 - 磁力测定法（DNVM）。基于词典的匹配型算法使用Axon-Hillock的APMF签名应用于数据，允许在单细胞分辨率下在脑组织的体积中对AP的时空重建。因此，增强APMF信号与NVMM的进展相结合，可以潜在地替代当前功能性脑映射技术。
Magnetic field sensing, with its recent advances, is emerging as a viable alternative to measure functional activity of single neurons in the brain by sensing action potential associated magnetic fields (APMFs). Measurement of APMFs of large axons of worms have been possible due to their size. In the mammalian brain, axon sizes, their numbers and routes, restricts using such functional imaging methods. With segmented model of mammalian pyramidal neurons, we show that the APMF of intra-axonal currents in the axon hillock are two orders of magnitude larger than other neuronal locations. Expected 2-dimensional vector magnetic field maps of naturalistic spiking activity of a volume of neurons via widefield diamond-nitrogen-vacancy-center-magnetometry (DNVM) were simulated. A dictionary based matching pursuit type algorithm applied to the data using the axon-hillock's APMF signature allowed spatiotemporal reconstruction of APs in the volume of brain tissue at single cell resolution. Enhancement of APMF signals coupled with NVMM advances thus can potentially replace current functional brain mapping techniques.
