论文标题
代谢图，生命法和药物作用在结核分枝杆菌上的建模
Metabolic graphs, LIFE method and the modeling of drug action on Mycobacterium tuberculosis
论文作者
论文摘要
本文是设计用于代谢药物作用的先进模型的框架。药物治疗可能通过增强或抑制包括代谢网络的代谢反应来影响代谢。我们介绍了\ textit {代谢图}的概念，这是具有代谢网络常见的专门特征的超图的概括。线性 - 浮温表达（短暂寿命）是一种分析代谢网络和模拟虚拟患者的方法。我们将生命动力学扩展到与代谢图兼容的，包括影响生化反应的增强子和抑制剂分子的更复杂的相互作用。我们讨论了考虑到代谢图上存在和唯一性所需的网络结构的结果，并在\ textit {结核分枝杆菌}上显示了药物作用的模拟（短暂的mtb）
This paper serves as a framework for designing advanced models for drug action on metabolism. Drug treatment may affect metabolism by either enhancing or inhibiting metabolic reactions comprising a metabolic network. We introduce the concept of \textit{metabolic graphs}, a generalization of hypergraphs having specialized features common to metabolic networks. Linear-in-flux-expression (briefly LIFE) is a methodology for analyzing metabolic networks and simulating virtual patients. We extend LIFE dynamics to be compatible with metabolic graphs, including the more complex interactions of enhancer and inhibitor molecules that affect biochemical reactions. We discuss results considering network structure required for existence and uniqueness of equilibria on metabolic graphs and show simulations of drug action on \textit{Mycobacterium tuberculosis} (briefly MTB)
