论文标题
覆盖有肌动蛋白套覆盖的膜纳米管的波动
Fluctuations of a membrane nanotube covered with an actin sleeve
论文作者
论文摘要
许多生物学功能依赖于细胞膜的重塑，尤其是纳米管，这些纳米管被动态肌动蛋白网络覆盖在体内。纳米管会受到热波动的影响，但这些对细胞功能的影响尚不清楚。在这里，我们使用粘附在脂质体膜上的光学捕获的珠子从脂质体形成纳米管。从该珠的功率谱密度来看，我们研究了体内测得的膜张力范围的纳米管波动。我们表明，覆盖纳米管的肌动蛋白套筒由于网络粘弹性而导致其高频波动。我们的工作为进一步研究纳米管波动在细胞功能中的影响铺平了道路。
Many biological functions rely on the reshaping of cell membranes, in particular into nanotubes, which are covered in vivo by dynamic actin networks. Nanotubes are subject to thermal fluctuations, but the effect of these on cell functions is unknown. Here, we form nanotubes from liposomes using an optically trapped bead adhering to the liposome membrane. From the power spectral density of this bead, we study the nanotube fluctuations in the range of membrane tensions measured in vivo. We show that an actin sleeve covering the nanotube damps its high frequency fluctuations because of the network viscoelasticity. Our work paves the way for further studies on the effect of nanotube fluctuations in cellular functions.
