论文标题
局部免疫缺陷：中性病毒的作用
Local Immunodeficiency: Role of Neutral Viruses
论文作者
论文摘要
本文分析了中性病毒在局部免疫缺陷现象中的作用。我们表明，即使没有利他病毒，中性病毒也可以支持持续性病毒的存在，从而支持局部免疫缺陷。但是，在所有此类情况下，中性病毒都可以保持持续病毒的有限浓度（相对较小）。此外，在所有这种情况下，局部免疫缺陷的状态只能略有稳定，而众所周知，利他病毒可以维持稳定的局部免疫缺陷。我们还提供了一个绝对最小的跨免疫反应性网络，可以维持稳定的局部免疫缺陷状态。现在，要建立具有稳定局部免疫缺陷的小型网络的合成生物学是一个挑战。生物学的另一个重要挑战是了解哪种类型的病毒可以发挥持久性，对比性和中性的作用，以及给定病毒扮演的作用是否取决于给定的交叉免疫反应网络的结构（拓扑）。
This paper analyzes the role of neutral viruses in the phenomenon of local immunodeficiency. We show that, even in the absence of altruistic viruses, neutral viruses can support the existence of persistent viruses, and thus local immunodeficiency. However, in all such cases neutral viruses can maintain only bounded (relatively small) concentration of persistent viruses. Moreover, in all such cases the state of local immunodeficiency could only be marginally stable, while it is known that altruistic viruses can maintain stable local immunodeficiency. We also present an absolutely minimal cross-immunoreactivity network where a stable and robust state of local immunodeficiency can be maintained. It is now a challenge to synthetic biology to build such small networks with stable local immunodeficiency. Another important challenge for biology is to understand which types of viruses can play a role of persistent, altrustic and neutral ones, and whether a role which a given virus plays depends on the structure (topology) of a given cross-immunoreactivity network.
