论文标题
在淀粉样蛋白生成序列的边界上：PDB \ _amyloid Collection中平行β表的前缀分析
On the Border of the Amyloidogenic Sequences: Prefix Analysis of the Parallel Beta Sheets in the PDB\_Amyloid Collection
论文作者
论文摘要
如今，蛋白质数据库（PDB）包含153,000多个条目，并带有生物大分子的3维结构。使用此存储库的丰富资源，可以识别具有针对不同应用程序的特定有趣属性的子集。我们的研究小组准备了一个自动更新的淀粉样蛋白 - 可能是淀粉样蛋白生成分子的列表，即PDB \ _amyloid Collection，可在地址\ url {http://pitgroup.org.org/amyloid}中免费获得。该资源仅应用空间结构的几何特性来识别淀粉样蛋白。在目前的贡献中，我们分析了PDB \ _amyloid集合中结构的特征性β片的起始（即前缀）子序列，并确定整个PDB数据集中这些长度5前缀子序列的进一步出现。我们已经确定了许多蛋白质，其正常或不规则功能涉及淀粉样蛋白的形成，结构错误折叠或抗凝集性特性，仅通过包含这些前缀：包括与主要的组织相容性MHC-1和MHC-2结合的T-Cell受体（TCR）； p53肿瘤抑制蛋白；分枝杆菌RNA聚合酶转录初始化复合物；人桥构成蛋白bin-1；和tick抗凝蛋白肽水龙头。
The Protein Data Bank (PDB) today contains more than 153,000 entries with the 3-dimensional structures of biological macromolecules. Using the rich resources of this repository, it is possible identifying subsets with specific, interesting properties for different applications. Our research group prepared an automatically updated list of amyloid- and probably amyloidogenic molecules, the PDB\_Amyloid collection, which is freely available at the address \url{http://pitgroup.org/amyloid}. This resource applies exclusively the geometric properties of the steric structures for identifying amyloids. In the present contribution, we analyze the starting (i.e., prefix) subsequences of the characteristic, parallel beta-sheets of the structures in the PDB\_Amyloid collection, and identify further appearances of these length-5 prefix subsequences in the whole PDB data set. We have identified this way numerous proteins, whose normal or irregular functions involve amyloid formation, structural misfolding, or anti-coagulant properties, simply by containing these prefixes: including the T-cell receptor (TCR), bound with the major histocompatibility complexes MHC-1 and MHC-2; the p53 tumor suppressor protein; a mycobacterial RNA polymerase transcription initialization complex; the human bridging integrator protein BIN-1; and the tick anti-coagulant peptide TAP.
