论文标题
机械化学酶和蛋白质机作为流体动力偶极子：活性二聚体模型
Mechanochemical enzymes and protein machines as hydrodynamic force dipoles: The active dimer model
论文作者
论文摘要
机械性活性酶在每个周转周期内都会改变其形状。因此，它们在周围的溶剂中诱导循环流动，并作为振荡的流体动力偶极子行为。由于酶共同产生的非平衡波动，在溶液中混合并预计其中的被动颗粒的扩散会得到增强。在这里，我们研究了这种力偶极子在机械化学酶的最小活性二聚体模型中的强度和统计特性。在该模型的框架中，得出了溶液中流体动力集体效应的新估计，并在快速旋转扩散下的脂质双层中进行了研究，并检查了可用的实验和计算数据。
Mechanochemically active enzymes change their shapes within every turnover cycle. Therefore, they induce circulating flows in the solvent around them and behave as oscillating hydrodynamic force dipoles. Because of non-equilibrium fluctuating flows collectively generated by the enzymes, mixing in the solution and diffusion of passive particles within it are expected to get enhanced. Here, we investigate the intensity and statistical properties of such force dipoles in the minimal active dimer model of a mechanochemical enzyme. In the framework of this model, novel estimates for hydrodynamic collective effects in solution and in lipid bilayers under rapid rotational diffusion are derived, and available experimental and computational data is examined.
