论文标题
生物分子网络的建模技术
Modelling techniques for biomolecular networks
论文作者
论文摘要
首先，我们不久将回顾系统生物学的不同类型的网络建模方法，重点是逻辑模型的不同子类型，我们会更详细地回顾一下。然后，我们显示了布尔网络模型的优势，而不是更机械的建模类型（例如微分方程技术）。然后遵循有关不同类型模型之间的连接以及如何将它们相互转换的忽视。我们还提供了有关用于建模逻辑网络的数学框架的简短概述，并列出了用于逻辑建模的可用软件包。然后，我们概述了用于存储此类逻辑系统生物学模型及其结果的可用标准和本体。最后，我们简要审查了定量模型和定性模型之间的差异，并描述了专门针对定性建模的数学。
First we shortly review the different kinds of network modelling methods for systems biology with an emphasis on the different subtypes of logical models, which we review in more detail. Then we show the advantages of Boolean networks models over more mechanistic modelling types like differential equation techniques. Then follows an overlook about connections between different kinds of models and how they can be converted to each other. We also give a short overview about the mathematical frameworks for modelling of logical networks and list available software packages for logical modelling. Then we give an overview about the available standards and ontologies for storing such logical systems biology models and their results. In the end we give a short review about the difference between quantitative and qualitative models and describe the mathematics that specifically deals with qualitative modelling.
